動漫電影《布偶大電影之最高通緝》又名《布偶大電影2》、《布偶歷險記：全面追緝》講述布偶們到歐洲巡演，來到了柏林、馬德里和倫敦游玩，不知不覺就與一個國際犯罪組織發生了瓜葛，這個組織由世界頭號罪犯康斯坦丁領導，他還有一個跟班——世界第二號罪犯多米尼克。多米尼克由瑞奇·熱維斯飾演，泰·布利爾將飾演一名國際刑警，蒂娜·菲將扮演一名霸氣的俄國監獄看守?？泼淄軐⒚鎸ψ畲蟮奶魬穑翰寂紙F正在進行歐洲巡演，到達了柏林、馬德里、倫敦等令人興奮的城市。但很快一個和科米蛙長得幾乎一模一樣，卻操著一口帶有濃重俄國口音英語的青蛙大盜康斯坦丁，搖身一變，和他的搭檔多米尼克(瑞奇·熱維斯飾演)混入了布偶團，而可憐的科米蛙則被蒂娜·菲飾演的獄警娜佳打入大牢，身陷囹圄。此外，《摩登家庭》男星泰·布利爾將飾演國際刑警，調查這樁奇怪的案件。

Flush with their revival's success, Kermit the Frog and his friends are approached by Dominic Badguy to go on a world tour. Unknown to them, this is all part of the sinister plan of Constantine, the world's most evil frog, to become the greatest thief of all time. After making sure that Kermit is jailed as himself, Constantine impersonates him to use the Muppets' tour as cover for his scheme. While Sam the Eagle and Inspector Jean Pierre Napoleon investigate, the Muppets find their boss seems strangely changed even as Kermit desperately attempts to escape to stop the impostor. Only when Walter, Fozzie and Animal realize the truth is there a chance to prevent Constantine from pulling off the crime of the century.